Genetic architecture of tauopathies Lead Investigator: Rahul Desikan Institution : University of California, San Diego E-Mail : rahuldesikan@gmail.com Proposal ID : 447 Proposal Description: Tauopathies are a class of neurodegenerative diseases associated with the neuropathological accumulation of the protein tau. Despite recent advances in better understanding the molecular basis of various tauopathies, the underlying genetic architecture of these dementias is still unknown. Here, using recently developed methods to assess genetic pleiotropy, we will evaluate genetic overlap among a number of neurodegenerative tauopathies. Our goal will be to: 1) provide insights into shared pathobiology and 2) identify single nucleotide polymorphisms associating with individual tauopathies.